Acquired hyperpigmentation is widespread in the population and significantly affects the quality of life of the patients. It is known that one of the clinical signs of skin hyperpigmentation is localized hyperkeratosis in the lesion associated with a high level of cell proliferation and cell saturation with melanin. Cellular proliferation and hyperkeratosis are associated with increased local metabolism rates.The phenomenon of skin hyperpigmentation is accompanied by a restructuring of blood cell metabolism aimed at preserving oxygen and energy homeostasis of skin structures. The obtained data indicate redistribution of oxygen in cellular structures and tissues, which is accompanied by a significant increase in lactate concentration and formation of local tissue hypoxia.