Nalini Kaul
Princeton Consumer Research, CanadaPresentation Title:
A clinical study assessing Deodorant efficacy, safety, Axilla hyperpigmentation and skin undertone
Abstract
Sweat odor is also known as bromhidrosis, is caused by bacteria on the skin breaking down acids in sweat. It is -unpleasant elicits disgust and impacts our confidence and social acceptance. The bacteria, such as Staphylococcus hominis, feed on odorless chemicals in the sweat and convert them into thioalcohols, which are pungent compounds that cause the smell. At the same time underarm discoloration makes us avoid wearing short sleeves, not participate in activities like swimming, physical exercise or other sports for fear of people commenting on the discoloration.
While deodorants are in use to combat and contain odor, there is need for products to help eliminate the axilla discoloration and improve its skin undertone as well. Every year there are many new products being introduced that claim all sorts of outrageous efficacy claims, and there is a need - to have a closer look to see if they do what it says on the tin!
Our objective was to evaluate the efficacy, safety and acceptability of deodorant product in a clinical design involving a human sensorial assessment method with multiple expert odor testers /sniffers to evaluate the odor levels and use of colorimetric measurements and professional photography to evaluate hyperpigmentation and skin undertone of the axilla region.
A randomized, blinded clinical study in healthy volunteers (18-67y) involved testing of two deodorants, two body wash products (30 volunteers each). Subjects were to abstain from the use of any deodorant product for ten days prior to the study, to use only the provided unscented body wash for all body washing needs. Shaving was only permitted 3 days before study start and not during the study. Subjects had to abide by strict study restrictions/ prohibitions including limitations on swimming/using hot tubs and eating certain kind of foods. The deodorant efficacy design involved a 12-day trial with controlled washes at day ( -1) and days (1-10). T-shirts were provided to be worn by subjects at Day -1, 10 to for 24-hr wear, and day 11 for 48-hour wear. following controlled washing. Expert visual evaluations for the respective body area were carried out on day 1, day 2-9, 11 and 13 and expert. For hyperpigmentation and skin undertone we had colorimetric measurements and professional photography at baseline, week 4, 8 and week 12.
Our results from sensory analysis showed that the deodorants were significantly effective in controlling malodor, safe to use. Visual grading for hyperpigmentation and underarm skin tone and Colorimetric value L* indicated a lightness/brightness of the skin, improvement in hyperpigmentation at all time points. Professional photography further confirmed these results.
In conclusion the product tested proved to be efficacious, safe while reducing sweat odor and axilla hyperpigmentation and in improving the skin undertone.
Biography
Dr. Nalini Kaul has a wealth of expertise working in a variety of clinical trials, regulatory affairs, and research-related capacities She completed her Master of Science in Biochemistry from Kashmir University in India and her PhD. from the reputed PGIME&R Chandigarh, India. She got her post-doctoral training at St Boniface General Hospital Winnipeg Canada and at the University of Southern California, USA. Thereafter she took a Senior Scientist position at the University of Dallas, Texas. Following her return to Canada in 2000 she worked as Technical Director on Clinical trials with Hill Top Research and then, moved on to hold a joint appointment as Sr. Director of Regulatory Affairs and Director of Clinical Trials with Source Nutraceutical Inc. In addition to providing scientific and regulatory support, Source Nutraceutical, Inc. built and oversaw a clinical trials unit and maintained communication with contract laboratories and clinical trial locations. She currently serves as Vice President of Technical Services at Princeton Consumer Research, a CRO that conducts clinical trials for clients in the UK and North America. As a technical expert, she provides clients with advice and consultation. Numerous studies pertaining to skin, antiaging, hair care, dandruff, photobiology, nutritional supplements, probiotics, the microbiome, and other topics had she participated in as an investigator. In addition to having numerous book chapters, magazine pieces, and other written works to her credit, she has published forty papers in national and international journals. She has also given numerous presentations at both national and International conferences.
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