Tatiana A. Gaydina

Pirogov Russian Scientific Research Medical University, Russia

Title: Annular elastolytic giant cell granuloma in a patient with Ehlers–Danlos syndrome


A clinical case of annular elastolytic giant cell granuloma (AEGCG) in a young patient with a vascular type of Ehlers–Danlos syndrome. The first clinical manifestations of AEGCG appeared on the skin in the right subclavian area about two years ago. Subsequently, new rashes appeared on the skin of the upper and lower extremities up to four new foci per year. The patient underwent ambulatory therapy as a solution of calcium gluconate 10% 5.0 ml No 10 i/v in every other day; a solution of chloropyramine hydrochloride 1.0 ml No 10 i/m every other day; betamethasone + salicylic acid ointment applied to the affected areas of the skin 2 times a day for 2 weeks. The treatment was ineffective, the rashes did not regress. External therapy with tacrolimus was carried out next, 0.1% ointment 2 times a day in the form of applications for 24 weeks but also without effect. The patient by herself started to take a dietary supplement containing 400 mg of collagen in 1 tablet; 3 types of amino acids 20 mg; vitamins B2 1.1 mg; B6 1.5 mg; calcium pantothenate 5 mg 2 tablets a day during meals. A month after the start of the application, she noticed a slight paling of the rashes. At the moment, the patient is under follow up.


Tatiana A. Gaydina, MD, PhD, assistant professor at Pirogov Russian Scientific Research Medical University, Moscow, Russia, has completed her PHD in 2011, the author of more than 30 scientific papers, including 15 publications over the past three years, 10 learning programs, teaching aids for students, and her publication h-index is 5. She has been serving as an editorial board member of several reputed journals.