Objective

Exosomes have emerged as a promising therapeutic modality for treatment of androgenic alopecia which can lead to phenomenal results in a short period of time. In recent years, scientists have made exciting breakthroughs in understanding how cells communicate through tiny vesicles called exosomes. These discoveries are helping us map out the complex web of cellular interactions and signaling pathways that exosomes facilitate bringing us close to unlocking their potential in health in the treatment of androgenic alopecia. This research sought to investigate the efficacy of salmon’s tissue derived exosomes could boost hair growth in AGA patients when applied into the scalp through microneedling.

Materials and methods 

This prospective study enrolled five participants: three male patients (aged 25-34 years) with androgenic alopecia (Norwood-Hamilton III-VI) and two female patients at mean age of 29 years with female pattern hair loss (Ludwig I-II). Salmon tissue-derived exosomes were used, and hair density measurements were obtained using the ARAMO SG phototrichogram system. Markers CD31 and ki67 were used to assess the levels of dermal vascularization and cells’ proliferation of outer root sheath respectively. 

Results 

Phototrichogram analysis demonstrated a statistically significant increase in hair density as early as the second week following completion of four exosomes application procedure administered in conjunction with microneedling therapy. Histopathological analysis of scalp biopsies using immunohistochemical markers CD31 which is an endothelial cell marker and ki67 a proliferation marker demonstrated that topical administration of salmon-derived exosomes enhances perifollicular microvascularization and stimulates proliferative activity in hair follicle cells.

Conclusion 

Quantitative analysis revealed salmon-derived exosome therapy significantly enhanced hair density parameters while maintaining high treatment satisfaction levels. The intervention was well tolerated, with zero incidence of treatment-related adverse effects.

Dr. Karray Karim is a dedicated specialist whose professional passion is centered on the health, science, and aesthetics of hair and scalp. With a profound expertise in trichology the specialized branch of dermatology focused on hair loss and scalp disorders. Dr. Karim provides a diagnostic and therapeutic sanctuary for patients experiencing hair thinning, alopecia, and other trichological concerns. His practice is built on a foundation of deep, continually updated knowledge. Dr. Karim actively participates in leading Russian and international trichology conferences, seminars, and master classes, ensuring his methodologies reflect the most current global research and innovations. This commitment to advanced education allows him to move beyond superficial treatments, offering instead a comprehensive, evidence-based approach that investigates the root causes of hair loss, whether genetic, hormonal, nutritional, or autoimmune.